Drosophila melanogaster, body segmentation Helikar Tomas thelika@unmc.edu University of Nebraska - Lincoln 2014-02-17T13:34:20Z 2017-07-19T12:29:55Z 2015-11-15T19:54:44Z

<span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">WG_external is an external activator in the Body segmentation in drosophila 2013 model</span>

2015-11-15T19:54:44Z

This is an external activator of the Body Segmentation in Drosophila 2013 paper

2015-11-15T19:54:44Z

Wingless<div>UniProt ID: <a href="http://www.uniprot.org/uniprot/P09615" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P09615</a></div><div>Gene Name: wg</div><div>Gene ID: <span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">34009</span></div>

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Hedgehog (HH) segment polarity gene<div>UniProt ID: <a href="http://www.uniprot.org/uniprot/Q02936" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q02936</a></div><div>Gene Name: hh</div><div>Gene ID: <span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">42737</span></div>

2015-11-15T19:54:44Z

transcription factor Engrailed in drosophila segmentation

2015-11-15T19:54:44Z

Transcriptional active form of CI in Drosophila Segmentation

2015-11-15T19:54:44Z

Protein for the gene that expresses <font color="#4f4f4f" face="Arial, Verdana" size="2"><span style="line-height: 1.5em; background-color: rgb(255, 255, 255); orphans: 3; widows: 3;">Transmembrane receptor protein</span></font><span style="orphans: 3; widows: 3;">s patched (PTC) in drosophila segmentation</span><div>for more information: http://www.ncbi.nlm.nih.gov/mesh/67099744</div>

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Represents pH<div><br/></div><div>Phagocytosis (mouse) in coninfection for more info:</div><div>http://www.ncbi.nlm.nih.gov/mesh/68010587</div><div><hr/></div><div><br/></div><div>PH protein in the Drosophila segmentation model (2013)</div>

2015-11-15T19:54:44Z

Smoothened (SMO)<div>UniProt ID: <a href="http://www.uniprot.org/uniprot/Q29NW6" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q29NW6</a></div><div>Gene Name: smo</div><div>Gene ID: <span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">33196</span></div>

2017-07-19T12:29:55Z

Repressor protein gene CI<div>Gene Name: cI</div><div>Gene ID: <span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">1261955</span></div>

2015-11-15T19:54:44Z 2015-11-15T19:54:44Z

Patched (ptc) membrane protein<div>UniProt ID: <a href="http://www.uniprot.org/uniprot/P18502" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">P18502</a></div><div>Gene Name: ptc</div><div>Gene ID: <span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">35851</span></div>

2017-05-18T13:55:39Z

Transcriptionally repressive form of CI protein in Drosophila segmentation

2017-05-18T13:55:39Z 2015-11-15T19:54:44Z

<span style="background-color: rgb(255, 255, 255); color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 14.40000057220459px;">Cytosolic protein cubitus interruptus</span><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.40000057220459px; background-color: rgb(255, 255, 255);">For more information: http://www.ncbi.nlm.nih.gov/mesh/?term=cubitus+interruptus</div>

2015-11-15T19:54:44Z

Hedgehog Transcription factor for drosophila segmentation

2015-11-15T19:54:44Z

CIA in conjunction with SLP and not CIR regulate Wg [1,2]. wg in conjunction with either CIA and SLP and not CIR regulates wg itself [1,2].

"<span style="font-size: 10pt;">slp encodes two forkhead domain </span><span style="font-size: 10pt;">transcription factors with similar functions that activate </span><span style="font-size: 10pt;">wg transcription</span>" [1,2]

Wg positively regulates itself [1,2]

"<span style="font-size: 10pt;">CI is cleaved to form CIR, a transcriptional </span><span style="font-size: 10pt;">repressor that represses wg</span>" [1,2,3]

"<span style="font-size: 10pt;">When </span><span style="font-size: 10pt;">SMO is active, CI is converted to a transcriptional </span><span style="font-size: 10pt;">activator CIA that promotes the transcription of wg</span>" [1,2,3,4,5]

S_4 1 S_12 1 S_11 1 S_1 1 S_12 1 S_4 1 S_11 1

EN_protein positively regulates Hh, while CIR negatively regulates Hh [1,2]

CIR a transcriptional repressor that represses Hh transcription [1,2,4,5]

"EN, the homeodomain-containing product of the en gene, promotes the transcription of the hedgehog gene (hh)" [1,2,3]

S_9 1 S_11 1

WG_external positively regulates En and SLP in conjunction negatively regulates En [1,2]

SLP negatively regulates En [1,2]

WG_external positively regulates En [1,2]

S_16 1 S_12 1

CI_protein in conjunction with either hh_external or PTC_protein positively regulates CIA [1,2,3,4,5,6].

CI_protein in conjunction with either hh_external or PTC_protein positively regulates CIA [1,6].

S_14 1 S_5 1 S_17 1 S_14 1

<span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">ptc activates PTC_protein [1,2]. PTC_protein in conjunction with hh_external positively regulates PTC_protein [1,2].</span>

ptc activates PTC_protein [1,2]

PTC_protein self regulates [1,2]

"<span style="font-size: 10pt;">The important </span><span style="font-size: 10pt;">role of HH in the networkis re?ected in the fact that it </span><span style="font-size: 10pt;">affects the future expression of four other proteins (CIA,</span><span style="font-size: 10pt;"><br/></span><span style="font-size: 10pt;">CIR, PTC and PH) in the neighboring cells</span>" [1,2]

S_10 1 S_5 1 S_17 1

PTC_protein in conjunction with hh_external positively regulates PH [1,2]

<div>"The important <span style="font-size: 10pt;">role of HH in the networkis re?ected in the fact that it </span><span style="font-size: 10pt;">affects the future expression of four other proteins (CIA,</span></div><div>CIR, PTC and PH) in the neighboring cells" [1,2]</div>

S_5 1 S_17 1

PTC_protein positively regulates SMO. hh_external positively regulates SMO. [1,2,3]

"<span style="font-size: 10pt;">Binding of HH </span><span style="font-size: 10pt;">to PTC removes the inhibition of SMO" [1,2,3]</span>

S_17 1 S_5 1 S_17 1

EN_protein positively regulates Ci [1,2,3].

<span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">"</span><span style="font-size: 10pt;">EN contains a </span><span style="font-size: 10pt;">separate repression domain </span><span style="font-size: 10pt;">that affects the transcription of ci" [1,2,3]</span>

S_9 1

en positively regulates EN_protein [1,2]

"WG_external and SLP in conjunction positively regulate En" [1,2]

S_3 1

CIA and EN_protein and not CIR positively regulate Ptc [1,2]

S_4 1 S_9 1 S_11 1

CI_protein and PTC_protein and hh_external work in conjunction to positively regulates CIR [1,2].

<div>"existence of PTC in those cells is very important because <span style="font-size: 10pt;">their signaling maintains the production of CIR" [1]</span></div><div>CI_protein and PTC_protein and hh_external work in conjunction to positively regulates CIR [1,2].</div>

CI_protein and PTC_protein and hh_external work in conjunction to positively regulates CIR [1,2].

S_14 1 S_5 1 S_17 1

wg positively regulates WG_protein [1,2]

The segment polarity gene, wg, encodes for the transcription factor WG_protein [1,2]

S_1 1

ci positively regulates CI_protein [1,2].

S_8 1

hh positively regulates HH_protein [1,2]

<span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">hh positively regulates HH_protein [1,2]</span>

S_2 1